|주요논문 (최근 5년간)
- -The chalcone derivative Chana 1 protects against amyloid β peptide-induced oxidative stress and cognitive impairment.Kwak J, Kim MJ, Choi KC, Choi HK, Jun W, Park HJ, Lee YH, Yoon HG.Int J Mol Med. 2012 Jul;30(1):193-8.
-EGCG suppresses prostate cancer cell growth modulating acetylation of androgen receptor by anti-histone acetyltransferase activity.Lee YH, Kwak J, Choi HK, Choi KC, Kim S, Lee J, Jun W, Park HJ, Yoon HG. Int J Mol Med. 2012 Jul;30(1):69-74.
-Inhaled essential oil from Chamaecyparis obtuse ameliorates the impairments of cognitive function induced by injection of β-amyloid in rats. Bae D, Seol H, Yoon HG, Na JR, Oh K, Choi CY, Lee DW, Jun W, Lee KY, Lee J, Hwang K, Lee YH, Kim S. Pharm Biol. 2012 Apr 3. →Epub ahead of print→
-Protective effects of a chalcone derivative against Aβ-induced oxidative stress and neuronal damage.Kim MJ, Lee YH, Kwak J, Na Y, Yoon HG.BMB Rep. 2011 Nov;44(11):730-4.
-Gallic acid, a histone acetyltransferase inhibitor, suppresses β-amyloid neurotoxicity by inhibiting microglial-mediated neuroinflammation. Kim MJ, Seong AR, Yoo JY, Jin CH, Lee YH, Kim YJ, Lee J, Jun WJ, Yoon HG. Mol Nutr Food Res. 2011 Dec;55(12):1798-808
-Delphinidin, a specific inhibitor of histone acetyltransferase, suppresses inflammatory signaling via prevention of NF-κB acetylation in fibroblast-like synoviocyte MH7A cells. Seong AR, Yoo JY, Choi K, Lee MH, Lee YH, Lee J, Jun W, Kim S, Yoon HG. Biochem Biophys Res Commun. 2011 Jul 8;410(3):581-6.
-Grape seed extract regulates androgen receptor-mediated transcription in prostate cancer cells through potent anti-histone acetyltransferase activity. Park SY, Lee YH, Choi KC, Seong AR, Choi HK, Lee OH, Hwang HJ, Yoon HG.J Med Food. 2011 Jan-Feb;14(1-2):9-16.
-Neuroprotective effects of Eriobotrya japonica against β-amyloid-induced oxidative stress and memory impairment.Kim MJ, Lee J, Seong AR, Lee YH, Kim YJ, Baek HY, Kim YJ, Jun WJ, Yoon HG.Food Chem Toxicol. 2011 Apr;49(4):780-4. Epub 2010 Dec 17.
-Procyanidin B3, an inhibitor of histone acetyltransferase, enhances the action of antagonist for prostate cancer cells via inhibition of p300-dependent acetylation of androgen receptor.Choi KC, Park S, Lim BJ, Seong AR, Lee YH, Shiota M, Yokomizo A, Naito S, Na Y, Yoon HG.Biochem J. 2011 Jan 1;433(1):235-44. Erratum in: Biochem J. 2011 Jan 14;433(3):535. Sung, Ah-Reum →corrected to Seong, Ah-Reum→.
-HDAC3 selectively represses CREB3-mediated transcription and migration of metastatic breast cancer cells. Kim HC, Choi KC, Choi HK, Kang HB, Kim MJ, Lee YH, Lee OH, Lee J, Kim YJ, Jun W, Jeong JW, Yoon HG.Cell Mol Life Sci. 2010 Oct;67(20):3499-510.
-The potential effects of ethyl acetate fraction from Curcuma longa L. on lipolysis in differentiated 3T3-L1 adipocytes. Lee J, Yoon HG, Lee YH, Park J, You Y, Kim K, Jang JY, Yang JW, Jun W.J Med Food. 2010 Apr;13(2):364-70.
-Histone deacetylase 3 is selectively involved in L3MBTL2-mediated transcriptional repression.Yoo JY, Choi KC, Kang H, Kim YJ, Lee J, Jun WJ, Kim MJ, Lee YH, Lee OH, Yoon HG.FEBS Lett. 2010 Jun 3;584(11):2225-30.
-.In vitro and in vivo hepatoprotective effects of the aqueous extract from Taraxacum officinale (dandelion) root against alcohol-induced oxidative stress.You Y, Yoo S, Yoon HG, Park J, Lee YH, Kim S, Oh KT, Lee J, Cho HY, Jun W.
Food Chem Toxicol. 2010 Jun;48(6):1632-7.
-Proteomic analysis of the protective effects of Platycodi Radix in liver of chronically alcoholic rats.An JH, Kim DS, Lee YH, Ho JN, Kim HK, Kang OJ, Shin IS, Cho HY.J Med Food. 2009 Dec;12(6):1190-8.
- Gallic acid suppresses lipopolysaccharide-induced nuclear factor-kappaB signaling by preventing RelA acetylation in A549 lung cancer cells. Choi KC, Lee YH (co-first), Jung MG, Kwon SH, Kim MJ, Jun WJ, Lee J, Lee JM, Yoon HG.Mol Cancer Res. 2009 Dec;7(12):2011-21.
-Stimulatory effects of ferulic acid on endurance exercise capacity in mice.
You Y, Park J, Yoon HG, Lee YH, Hwang K, Lee J, Kim K, Lee KW, Shim S, Jun W.
Biosci Biotechnol Biochem. 2009 Jun;73(6):1392-7.
-The histone methyltransferase, NSD2, enhances androgen receptor-mediated transcription.Kang HB, Choi Y, Lee JM, Choi KC, Kim HC, Yoo JY, Lee YH, Yoon HG. FEBS Lett. 2009 Jun 18;583(12):1880-6.
- Epigallocatechin-3-gallate, a histone acetyltransferase inhibitor, inhibits EBV-induced B lymphocyte transformation via suppression of RelA acetylation.
Choi KC, Jung MG, Lee YH, Yoon JC, Kwon SH, Kang HB, Kim MJ, Cha JH, Kim YJ, Jun WJ, Lee JM, Yoon HG.Cancer Res. 2009 Jan 15;69(2):583-92.
-Choi HK, Choi KC, Oh SY, Kang HB, Lee YH, Haam S, Ahn YH, Kim KS, Kim K, Yoon HG.
The functional role of the CARM1-SNF5 complex and its associated HMT activity in transcriptional activation by thyroid hormone receptor.
Exp Mol Med. 2007 Aug 31;39(4):544-55.
-Choi KC, Oh SY, Kang HB, Lee YH, Haam S, Kim HI, Kim K, Ahn YH, Kim KS, Yoon HG.
The functional relationship between co-repressor N-CoR and SMRT in mediating transcriptional repression by thyroid hormone receptor alpha.
Biochem J. 2008 Apr 1;411(1):19-26.
-Choi HK, Choi KC, Kang HB, Kim HC, Lee YH, Haam S, Park HG, Yoon HG.
Function of multiple Lis-Homology domain/WD-40 repeat-containing proteins in feed-forward transcriptional repression by silencing mediator for retinoic and thyroid receptor/nuclear receptor corepressor complexes.
Mol Endocrinol. 2008 May;22(5):1093-104.
-Ho JN, Lee YH, Park JS, Jun WJ, Kim HK, Hong BS, Shin DH, Cho HY.
Protective effects of aucubin isolated from Eucommia ulmoides against UVB-induced oxidative stress in human skin fibroblasts.
Biol Pharm Bull. 2005 Jul;28(7):1244-8.
-Ho JN, Lee YH, Lee YD, Jun WJ, Kim HK, Hong BS, Shin DH, Cho HY.
Inhibitory effect of Aucubin isolated from Eucommia ulmoides against UVB-induced matrix metalloproteinase-1 production in human skin fibroblasts.
Biosci Biotechnol Biochem. 2005 Nov;69(11):2227-31.
- Lee YH, Myung Gu Jung, Hee Bum Kang, Kyung-Chul Choi, Seungjoo Haam, Woojin Jun, Young-Jun Kim, Hong Yon Cho and Ho-Geun Yoon
Effect of anti-histone acetyltransferase activity from Rosa rugosa Thunb.(Rosaceae) extracts on androgen receptor-mediated transcriptional regulation
Journal of ethnopharmacology, accepted 2008.
- Lee YH, Hong SW, Jun W, Cho HY, Kim HC, Jung MG, Wong J, Kim HI, Kim CH, Yoon HG.
Anti-histone acetyltransferase activity from allspice extracts inhibits androgen receptor-dependent prostate cancer cell growth.
Biosci Biotechnol Biochem. 2007 Nov;71(11):2712-9
-Lee YH, Kim YJ, Kim HI, Cho HY, Yoon HG
Research Articles : Potent HAT Inhibitory Effect of Aqueous Extract from Bellflower (Platycodon grandiflorum) Roots on Androgen Receptor-mediated Transcriptional Regulation
Food Science and Biotechnology , 2007, |16( 3), 457 ~ 462
-Lee YH, Ho JN, Dong MS, Park CH, Kim HK, Hong BS, Shin DH, Cho HY
Transfected HepG2 Cells for Evaluation of Catechin Effects on Alcohol-Induced CYP2E1 Cytotoxicity
J. Microbiol. Biotechnol. 2005 15, 6:1310-1316
1. 10-0657017 도라지 추출물을 함유하는 L-FABP 증강제 및 그 정제방법(2006)
2. 10-0657018 알코올성 감섬유화 예방 및 치료용 식물유래 추출물. (2006)
3. 10-0830236 도라지 추출물을 함유하는 전립선암 예방 및 치료용 조성물(2008)